Contact sensitization to hydroperoxides of limonene and linalool: Results of consecutive patch testing and clinical relevance.

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Contact sensitization to hydroperoxides of limonene and linalool: Results of consecutive patch testing and clinical relevance.

Contact Dermatitis. 2018 Oct 31;:

Authors: Dittmar D, Schuttelaar MLA

Abstract
BACKGROUND: Hydroperoxides of limonene and linalool are potent sensitizers.
OBJECTIVES: To investigate the prevalence of contact allergy to both hydroperoxides of limonene and hydroperoxides of linalool, to report clinical relevance, and to investigate patient demographics.
METHODS: A total of 821 patients (35.6% male, mean age 42.4 years?±?17.8?years) were consecutively patch tested with our departmental baseline series and our fragrance series, including hydroperoxides of limonene 0.3% pet. and hydroperoxides of linalool 1.0% pet. The clinical relevance was assessed for all positive reactions.
RESULTS: Positive patch test reactions to hydroperoxides of limonene and to hydroperoxides of linalool were observed in 77 patients (9.4%, 95% confidence interval [CI]: 7.4%-11.4%) and in 96 patients (11.7%, 95%CI: 9.5%-13.9%), respectively; 38 of these patients (4.6%, 95%CI: 3.2%-6.0%) reacted to both. Most reactions were considered to be possibly or probably clinically relevant (66.3% and 68.8%, respectively), and a small proportion were deemed to be of certain clinical relevance (18.2% and 19.8%, respectively).
CONCLUSION: As compared with previous studies, high numbers of positive reactions to both hydroperoxides of limonene and hydroperoxides of linalool were observed, the majority of which were clinically relevant, supporting their inclusion in the European baseline series.

PMID: 30378131 [PubMed – as supplied by publisher]

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[A woman with a growing mass close to the fingernail].

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[A woman with a growing mass close to the fingernail].

Ned Tijdschr Geneeskd. 2018 Sep 24;162:

Authors: Ferrari BR, Terra JB, van der Beek ESJ

Abstract
A 23-year-old woman had a painful, growing mass close to the nail of her left index finger. The differential diagnosis consisted of acquired digital fibrokeratoma, digital fibromyxoma, periungual fibroma or verruca vulgaris. Surgical excision of the mass was performed, and histopathological analysis revealed a subungual exostosis.

PMID: 30358362 [PubMed – in process]

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Allergic contact dermatitis caused by acrylic acid used in transcutaneous electrical nervous stimulation.

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Allergic contact dermatitis caused by acrylic acid used in transcutaneous electrical nervous stimulation.

Contact Dermatitis. 2017 Dec;77(6):409-412

Authors: Dittmar D, Dahlin J, Persson C, Schuttelaar ML

PMID: 29164695 [PubMed – indexed for MEDLINE]

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Cutaneous adverse drug reaction after apomorphine infusion, possibly caused by a systemic type IV hypersensitivity reaction to sodium metabisulfite: Report of 2 cases.

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Cutaneous adverse drug reaction after apomorphine infusion, possibly caused by a systemic type IV hypersensitivity reaction to sodium metabisulfite: Report of 2 cases.

Contact Dermatitis. 2018 Aug 19;:

Authors: Borgemeester RWK, van Laar T, Schuttelaar MLA

PMID: 30123968 [PubMed – as supplied by publisher]

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Cutaneous adverse drug reaction after apomorphine infusion, possibly caused by a systemic type IV hypersensitivity reaction to sodium metabisulfite: Report of 2 cases.

Related Articles

Cutaneous adverse drug reaction after apomorphine infusion, possibly caused by a systemic type IV hypersensitivity reaction to sodium metabisulfite: Report of 2 cases.

Contact Dermatitis. 2018 Aug 19;:

Authors: Borgemeester RWK, van Laar T, Schuttelaar MLA

PMID: 30123968 [PubMed – as supplied by publisher]

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Complete remission of skin lesions in a patient with subcorneal pustular dermatosis (Sneddon-Wilkinson disease) treated with antimyeloma therapy: association with disappearance of M-protein.

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Complete remission of skin lesions in a patient with subcorneal pustular dermatosis (Sneddon-Wilkinson disease) treated with antimyeloma therapy: association with disappearance of M-protein.

Br J Dermatol. 2017 May;176(5):1341-1344

Authors: von dem Borne PA, Jonkman MF, van Doorn R

Abstract
Subcorneal pustular dermatosis (SPD), or Sneddon-Wilkinson disease, is a rare pustular skin disease that follows a chronic relapsing course. A well-known association exists between SPD and IgA monoclonal gammopathy of undetermined significance (MGUS), which exists in up to 40% of cases. SPD has also been observed in patients with IgA myeloma. In SPD, direct and indirect immunofluorescence studies do not reveal in vivo bound IgA to the epithelial cell surface, in contrast to IgA pemphigus, which has similar clinicopathological features. Here we describe the case of a male patient with SPD and a concurrent IgA MGUS who had been treated with dapsone for 20 years with frequent relapses. Following development of multiple myeloma, the patient was treated with intensive antimyeloma treatment consisting of high-dose melphalan with autologous stem cell transplantation. This resulted in a complete remission of the myeloma with disappearance of the M-protein. In addition, a sustained remission of SPD was achieved without further treatment. Twenty-eight months after melphalan therapy the M-protein reappeared in the serum, and 2 months later SPD reappeared with histopathologically proven skin lesions at predilection sites. Presence and absence of skin lesions was found to correlate with the presence and absence of the M-protein in the serum. This is the first report of antimyeloma therapy inducing a long-lasting remission in SPD. The findings in this patient strongly suggest a causal role for circulating IgA antibodies in the pathogenesis of SPD. Antimyeloma treatment should be considered in patients with IgA MGUS-associated SPD refractory to other therapies.

PMID: 27516004 [PubMed – indexed for MEDLINE]

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Topical Gentamicin for the Treatment of Genetic Skin Diseases.

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Topical Gentamicin for the Treatment of Genetic Skin Diseases.

J Invest Dermatol. 2018 Apr;138(4):731-734

Authors: Pasmooij AMG

Abstract
Clinical application of topical gentamicin is a worthwhile option to investigate further for Nagashima-type palmoplantar keratosis and other genetic skin diseases caused by nonsense mutations. It is especially interesting to study gentamicin 1B because it may be more efficacious than other gentamicin components. Topical gentamicin has an acceptable safety profile, although prospective tracking of antibiotic resistance is warranted.

PMID: 29579455 [PubMed – in process]

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Image Gallery: Paraneoplastic pemphigus and follicular dendritic cell sarcoma.

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Image Gallery: Paraneoplastic pemphigus and follicular dendritic cell sarcoma.

Br J Dermatol. 2018 Feb;178(2):e146

Authors: Jonkman MF, Pas HH

PMID: 29441554 [PubMed – in process]

Posted in Br J Dermatol | Comments Off on Image Gallery: Paraneoplastic pemphigus and follicular dendritic cell sarcoma.

Comparing patch test results of methylchloroisothiazolinone/methylisothiazolinone tested with both TRUE Test® and 100?ppm using investigator-loaded chambers.

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Comparing patch test results of methylchloroisothiazolinone/methylisothiazolinone tested with both TRUE Test® and 100?ppm using investigator-loaded chambers.

Contact Dermatitis. 2018 Feb;78(2):159-161

Authors: Dittmar D, Schuttelaar ML

PMID: 29341185 [PubMed – in process]

Posted in Contact Dermatitis | Comments Off on Comparing patch test results of methylchloroisothiazolinone/methylisothiazolinone tested with both TRUE Test® and 100?ppm using investigator-loaded chambers.

Laboratory diagnosis of pemphigus: direct immunofluorescence remains the gold standard.

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Laboratory diagnosis of pemphigus: direct immunofluorescence remains the gold standard.

Br J Dermatol. 2016 Jul;175(1):185-6

Authors: Giurdanella F, Diercks GF, Jonkman MF, Pas HH

PMID: 26798993 [PubMed – indexed for MEDLINE]

Posted in Br J Dermatol | Comments Off on Laboratory diagnosis of pemphigus: direct immunofluorescence remains the gold standard.

Stevens Johnson syndrome/toxic epidermal necrolysis-overlap, induced by lacosamide.

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Stevens Johnson syndrome/toxic epidermal necrolysis-overlap, induced by lacosamide.

Eur J Dermatol. 2016 Apr 01;26(2):185-6

Authors: Kardaun SH, Vos BJ, Chandran NS

PMID: 27017922 [PubMed – indexed for MEDLINE]

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Two decades of p-phenylenediamine and toluene-2,5-diamine patch testing – focus on co-sensitizations in the European baseline series and cross-reactions with chemically related substances.

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Two decades of p-phenylenediamine and toluene-2,5-diamine patch testing – focus on co-sensitizations in the European baseline series and cross-reactions with chemically related substances.

Contact Dermatitis. 2017 Feb;76(2):81-88

Authors: Vogel TA, Heijnen RW, Coenraads PJ, Schuttelaar MA

Abstract
BACKGROUND: Cross-reactions and co-sensitizations are of great importance in understanding contact allergy and exposure sources.
OBJECTIVES: To investigate common cross-reactions and co-sensitizations in p-phenylenediamine (PPD)-sensitized and toluene-2,5-diamine (TDA)-sensitized individuals.
METHODS: From our patch test population, 8036 patients patch tested with the European baseline series were extracted. Readings had to be performed at least on day 3 according to ICDRG guidelines.
RESULTS: Two hundred and fifty-one patients were sensitized to PPD and/or TDA; 231 patients were sensitized to PPD, and 109 to TDA. Significant differences were observed regarding the strengths of patch test reactions to PPD and number of cross-reactions. For TDA, a difference was found between all reaction strengths, except between + and ++ strengths. PPD-sensitized individuals were more likely to be sensitized to carba mix, cobalt chloride, colophonium, p-tert-butyl phenolformaldehyde resin, paraben mix, and methylisothiazolinone. TDA-sensitized individuals were more often sensitized to carba mix.
CONCLUSIONS: Cross-reactivity was commonly found among individuals sensitized to PPD or TDA, and was strongly related to the strength of the patch test reaction. Regarding co-sensitizations, a frequently appearing or common exposure source could not be determined. However, modification of the allergen by, for example, the skin microbiota may have caused the formation of molecules that are, for the human immune system, indistinguishable from PPD.

PMID: 27555055 [PubMed – indexed for MEDLINE]

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Immunology and genetics of tumour necrosis factor in allergic contact dermatitis.

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Immunology and genetics of tumour necrosis factor in allergic contact dermatitis.

Contact Dermatitis. 2017 Mar 16;:

Authors: Dittmar D, Schuttelaar ML

Abstract
During the sensitization phase of allergic contact dermatitis, the proinflammatory cytokine tumour necrosis factor (TNF) plays an important role by promoting epidermal Langerhans cell migration to draining lymph nodes. It also plays a role during the elicitation phase. The TNF gene (TNF) is located within the major histocompatibility complex region. Many single-nucleotide variants exist in the promoter region of TNF, and these may either increase or decrease mRNA transcription and therefore lead to higher or lower levels of TNF. The most extensively studied single-nucleotide variant of TNF is a base pair substitution in the promoter region at location -308 relative to the transcription start site (rs1800629, TNF -308G>A), which is believed to increase transcription and lead to higher TNF levels. The role of TNF in allergic contact dermatitis and the functionality of TNF -308G>A are reviewed in this article. The association between genetic variants and disease can be studied in a case-control design. Only a few case-control studies investigating the association between TNF -308G>A and allergic contact dermatitis have been published, with contradictory results. These are reviewed critically, and suggestions for future case-control studies on this topic are given.

PMID: 28300283 [PubMed – as supplied by publisher]

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Acute localised exanthematous pustulosis: What are the diagnostic criteria?

Acute localised exanthematous pustulosis: What are the diagnostic criteria?

Australas J Dermatol. 2017 Feb;58(1):74

Authors: Kardaun SH

PMID: 28195325 [PubMed – in process]

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The Association between Hidradenitis Suppurativa and Crohn’s Disease: in Search of the Missing Pathogenic Link.

The Association between Hidradenitis Suppurativa and Crohn’s Disease: in Search of the Missing Pathogenic Link.

J Invest Dermatol. 2016 Sep;136(9):1747-8

Authors: van der Zee HH, Horvath B, Jemec GB, Prens EP

Abstract
Hidradenitis suppurativa is a chronic, autoinflammatory skin disease. Shalom et al. demonstrate in a large cross-sectional study an association between Crohn’s disease and hidradenitis suppurativa, but not with ulcerative colitis. This association supports the hypothesis that a similar pathogenic mechanism contributes to both diseases, providing new possibilities for functional studies and therapy development.

PMID: 27542293 [PubMed – in process]

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