Monthly Archives: September 2015

Drug survival of methotrexate treatment in hand eczema patients: results from a retrospective daily practice study.

Posted on September 17, 2015 by

Related Articles
Drug survival of methotrexate treatment in hand eczema patients: results from a retrospective daily practice study.
J Eur Acad Dermatol Venereol. 2015 Sep 14;
Authors: Politiek K, van der Schaft J, Ch… Continue reading →






Posted in J Eur Acad Dermatol Venereol | Comments Off on Drug survival of methotrexate treatment in hand eczema patients: results from a retrospective daily practice study.

Prevalence of contact allergy in the general population in different European regions.

Posted on September 17, 2015 by


Related Articles

Prevalence of contact allergy in the general population in different European regions.

Br J Dermatol. 2015 Sep 15;

Authors: Diepgen TL, Ofenloch RF, Bruze M, Bertuccio P, Cazzaniga S, Coenraads PJ, Elsner P, Goncalo M, Svensson Å, Naldi L

Abstract
BACKGROUND: Population-based studies about contact allergy are scarce.
OBJECTIVES: To obtain reliable estimates of prevalence of contact allergy in the general population in Europe.
METHODS: Cross-sectional study of a random sample from the general population, aged 18 to 74 years, in 5 different European countries (Sweden, The Netherlands, Germany, Italy, Portugal). In total 12,377 subjects were interviewed and a random sample (n=3,119) patch tested to TRUE-test panel 1, 2 and 3 plus fragrance mix II, HICC, and sesquiterpene lactone mix. A positive patch test reaction is considered as contact allergy.
RESULTS: In total, 27.0% (95% CI 25.5-28.5) had at least one positive reaction to an allergen of the European baseline series with a significant higher prevalence in females compared to males. The highest age-standardized prevalences (≥ 1%) were found for nickel (14.5%; 95% CI 13.2-15.8), thimerosal (5.0%; 95% CI 4.2-5.8), cobalt (2.2%; 95% CI 1.7-2.7), fragrance mix II (1.9%, 95% CI 1.5-2.5), fragrance mix I (1.8% 95% CI 1.4-2.3), hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC)(1.4%, 95% CI 1.0-1.9), p-tert-butylphenol- formaldehyde-resin (1.3%; 95% CI 0.9-1.7), and p-phenylenediamine (1.0%; 95% CI 0.6-1.3). Only Nickel and Thimerosal showed a statistically significant different prevalence for contact allergy amongst the different European populations. Subjects that reported contact dermatitis in lifetime (age-standardized prevalence 15.1%, 95%CI 13.8-16.3) had an increased risk for contact allergy (OR 1.9, 95% CI 1.5-2.5) the risk of having a contact allergy was not increase in those with atopic dermatitis (prevalence 7.6%, 95% CI 6.7-8.6; OR 1.0, 95% CI 0.7-1.4).
CONCLUSIONS: Contact allergy to at least one allergen of the European baseline series was diagnosed in more than one quarter of the general European population. Therefore measures to improve the primary prevention of contact allergy have to be enforced. This article is protected by copyright. All rights reserved.

PMID: 26370659 [PubMed – as supplied by publisher]

Continue reading →






Posted in Br J Dermatol | Comments Off on Prevalence of contact allergy in the general population in different European regions.

Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study.

Posted on September 7, 2015 by


Related Articles

Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study.

Ann Med. 2015 Sep 4;:1-8

Authors: Meems LM, de Borst MH, Postma DS, Vonk JM, Kremer HP, Schuttelaar MA, Rosmalen JG, Weersma RK, Wolffenbuttel BH, Scholtens S, Stolk RP, Kema IP, Navis G, Khan MA, van der Harst P, de Boer RA

Abstract
BACKGROUND: The prevalence of multimorbidity (≥ 1 disease within an individual) is rapidly increasing. So far, studies on the relationship between vitamin D and morbidity are mainly focusing on effects on single disease domains only, while vitamin D biology is associated with several diseases throughout the human body.
METHODS: We studied 8,726 participants from the LifeLines Cohort Study (a cross-sectional, population-based cohort study) and used the self-developed composite morbidity score to study the association between vitamin D levels and multimorbidity.
RESULTS: Study participants (mean age 45 ± 13 years, 73% females) had a mean plasma vitamin D level of 59 ± 22 nmol/L. In participants aged between 50 and 60 years, 58% had ≥ 2 affected disease domains, while morbidity score increased with age (70-80 years: 82% morbidity score > 1; > 80 years: 89% morbidity score > 1). Each incremental reduction by 1 standard deviation (SD) of vitamin D level was associated with an 8% higher morbidity score (full model OR 0.92, 95% CI 0.88-0.97, P = 0.001). Participants with vitamin D levels < 25 nmol/L were at highest risk for increasing morbidity prevalence (versus > 80 nmol/L, OR 1.34, 95% CI 1.07-1.67, P = 0.01).
CONCLUSIONS: Low levels of vitamin D are associated with higher prevalence of multimorbidity, especially in participants with vitamin D levels < 25 nmol/L. Collectively, our results favor a general, rather than an organ-specific, approach when assessing the impact of vitamin D deficiency.

PMID: 26340085 [PubMed – as supplied by publisher]

Continue reading →






Posted in Ann Med | Comments Off on Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study.

Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study.

Posted on September 7, 2015 by


Related Articles

Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study.

Ann Med. 2015 Sep 4;:1-8

Authors: Meems LM, de Borst MH, Postma DS, Vonk JM, Kremer HP, Schuttelaar MA, Rosmalen JG, Weersma RK, Wolffenbuttel BH, Scholtens S, Stolk RP, Kema IP, Navis G, Khan MA, van der Harst P, de Boer RA

Abstract
BACKGROUND: The prevalence of multimorbidity (≥ 1 disease within an individual) is rapidly increasing. So far, studies on the relationship between vitamin D and morbidity are mainly focusing on effects on single disease domains only, while vitamin D biology is associated with several diseases throughout the human body.
METHODS: We studied 8,726 participants from the LifeLines Cohort Study (a cross-sectional, population-based cohort study) and used the self-developed composite morbidity score to study the association between vitamin D levels and multimorbidity.
RESULTS: Study participants (mean age 45 ± 13 years, 73% females) had a mean plasma vitamin D level of 59 ± 22 nmol/L. In participants aged between 50 and 60 years, 58% had ≥ 2 affected disease domains, while morbidity score increased with age (70-80 years: 82% morbidity score > 1; > 80 years: 89% morbidity score > 1). Each incremental reduction by 1 standard deviation (SD) of vitamin D level was associated with an 8% higher morbidity score (full model OR 0.92, 95% CI 0.88-0.97, P = 0.001). Participants with vitamin D levels < 25 nmol/L were at highest risk for increasing morbidity prevalence (versus > 80 nmol/L, OR 1.34, 95% CI 1.07-1.67, P = 0.01).
CONCLUSIONS: Low levels of vitamin D are associated with higher prevalence of multimorbidity, especially in participants with vitamin D levels < 25 nmol/L. Collectively, our results favor a general, rather than an organ-specific, approach when assessing the impact of vitamin D deficiency.

PMID: 26340085 [PubMed – as supplied by publisher]

Continue reading →






Comments Off on Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study.

Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study.

Posted on September 7, 2015 by


Related Articles

Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study.

Ann Med. 2015 Sep 4;:1-8

Authors: Meems LM, de Borst MH, Postma DS, Vonk JM, Kremer HP, Schuttelaar MA, Rosmalen JG, Weersma RK, Wolffenbuttel BH, Scholtens S, Stolk RP, Kema IP, Navis G, Khan MA, van der Harst P, de Boer RA

Abstract
BACKGROUND: The prevalence of multimorbidity (≥ 1 disease within an individual) is rapidly increasing. So far, studies on the relationship between vitamin D and morbidity are mainly focusing on effects on single disease domains only, while vitamin D biology is associated with several diseases throughout the human body.
METHODS: We studied 8,726 participants from the LifeLines Cohort Study (a cross-sectional, population-based cohort study) and used the self-developed composite morbidity score to study the association between vitamin D levels and multimorbidity.
RESULTS: Study participants (mean age 45 ± 13 years, 73% females) had a mean plasma vitamin D level of 59 ± 22 nmol/L. In participants aged between 50 and 60 years, 58% had ≥ 2 affected disease domains, while morbidity score increased with age (70-80 years: 82% morbidity score > 1; > 80 years: 89% morbidity score > 1). Each incremental reduction by 1 standard deviation (SD) of vitamin D level was associated with an 8% higher morbidity score (full model OR 0.92, 95% CI 0.88-0.97, P = 0.001). Participants with vitamin D levels < 25 nmol/L were at highest risk for increasing morbidity prevalence (versus > 80 nmol/L, OR 1.34, 95% CI 1.07-1.67, P = 0.01).
CONCLUSIONS: Low levels of vitamin D are associated with higher prevalence of multimorbidity, especially in participants with vitamin D levels < 25 nmol/L. Collectively, our results favor a general, rather than an organ-specific, approach when assessing the impact of vitamin D deficiency.

PMID: 26340085 [PubMed – as supplied by publisher]

Continue reading →






Comments Off on Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study.