Monthly Archives: January 2016

Epiplakin Is a Paraneoplastic Pemphigus Autoantigen and Related to Bronchiolitis Obliterans in Japanese Patients.

Posted on January 25, 2016 by

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Epiplakin Is a Paraneoplastic Pemphigus Autoantigen and Related to Bronchiolitis Obliterans in Japanese Patients.
J Invest Dermatol. 2016 Feb;136(2):399-408
Authors: Tsuchisaka A, Numata S, Teye K, Na… Continue reading →






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Prevalence of Contact Allergy to p-Phenylenediamine in the European General Population.

Posted on January 25, 2016 by


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Prevalence of Contact Allergy to p-Phenylenediamine in the European General Population.

J Invest Dermatol. 2016 Feb;136(2):409-415

Authors: Diepgen TL, Naldi L, Bruze M, Cazzaniga S, Schuttelaar ML, Elsner P, Goncalo M, Ofenloch R, Svensson Å

Abstract
Population-based studies on contact allergy to p-phenylenediamine (PPD) are scarce. A cross-sectional study was performed to assess the prevalence of contact allergy to PPD and its risk factors in the general population of 5 European countries. A total of 10,425 subjects were interviewed, and a random sample (n = 2,739) was patch tested to PPD. Overall, 5,286 individuals (50.9%) reported having used hair colorants at least once in their lifetime (78% female, 20% male), and 35% had used hair colorants during the last 12 months. Hair colorant avoidance because of any skin problem during the lifetime was reported by 6%. Black henna tattoos had been used by 5.5% during their lifetime. The prevalence of PPD contact allergy was 0.8% (95% confidence interval 0.6-1.0%), with no statistically significant association with gender or hair dye use. The prevalence of PPD in black henna tattoo users was 3.2% versus 0.6% in nonusers (P < 0.001). A clinically relevant positive patch test reaction to PPD related to hair coloring products was found in 0.1% (95% confidence interval 0.0-0.2%). A significant association with PPD contact allergy was observed for subjects who had black henna tattoos in their lifetime, with an age- and gender-adjusted odds ratio of 9.33 (95% confidence interval 3.45-25.26, P < 0.001). Black henna tattoos are an important risk factor for PPD contact allergy.

PMID: 26802237 [PubMed – as supplied by publisher]

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Continuous usage of a hair dye product containing 2-methoxymethyl-p-phenylenediamine by hair dye allergic individuals.

Posted on January 15, 2016 by


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Continuous usage of a hair dye product containing 2-methoxymethyl-p-phenylenediamine by hair dye allergic individuals.

Br J Dermatol. 2016 Jan 8;

Authors: Kock M, Coenraads PJ, Blömeke B, Goebel C

Abstract
BACKGROUND: Despite a positive patch test reaction to p-phenylenediamine (PPD) and/or toluene-2,5-diamine (PTD) many people attempt to continue dyeing their hair with products containing PPD or its derivatives.
OBJECTIVES: Investigation of elicitation reactions among PPD/PTD allergic individuals to hair dye products containing the less-sensitizing PPD-derivative 2-methoxymethyl-p-phenylenediamine (ME-PPD).
METHODS: Elicitation reactions were studied in 43 PPD/PTD allergic individuals by a 45-min pre-test with a ME-PPD containing hair dye on their forearm and upon negative result followed by exposure to subsequent hair colour treatment(s).
RESULTS: 38/43 PPD/PTD allergic individuals did not develop an elicitation reaction during the pre-test with ME-PPD containing hair dye products and were eligible for subsequent hair colour treatments. Of these 38 PPD/PTD allergic individuals 29 tolerated subsequent hair dyeing with ME-PPD containing hair dye products while 9 showed mild to moderate allergic reactions upon the first hair colour treatment.
CONCLUSIONS: Hair dye products with the less sensitizing ME-PPD were tolerated by 29/43 (67%) PPD/PTD allergic individuals throughout continued hair dyeing with an average of 9 treatments per year. Five individuals reacted upon pre-testing while only mild to moderate skin reactions occurred upon hair dyeing in 9 individuals who were not identified by the pre-test. To our knowledge this is the first study among PPD/PTD allergic individuals indicating that a negative 45 min pre-testing with a hair dye product helps to avoid severe allergic reactions. This article is protected by copyright. All rights reserved.

PMID: 26749506 [PubMed – as supplied by publisher]

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Opinion of the Scientific Committee on Consumer safety (SCCS) – Opinion on the fragrance ingredients Tagetes minuta and T. patula extracts and essential oils (phototoxicity only) in cosmetic products.

Posted on January 5, 2016 by

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Opinion of the Scientific Committee on Consumer safety (SCCS) – Opinion on the fragrance ingredients Tagetes minuta and T. patula extracts and essential oils (phototoxicity only) in cosmetic products.
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