Monthly Archives: February 2016

Blistering disease: insight from the hemidesmosome and other components of the dermal-epidermal junction.

Posted on February 24, 2016 by Turcan I, Jonkman MF

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Blistering disease: insight from the hemidesmosome and other components of the dermal-epidermal junction.
Cell Tissue Res. 2015 Jun;360(3):545-69
Authors: Turcan I, Jonkman MF
Abstract
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Assessment of the elicitation response in subjects weakly sensitized to p-phenylenediamine.

Posted on February 24, 2016 by Pot LM, Coenraads PJ, Goebel C, Blömeke B


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Assessment of the elicitation response in subjects weakly sensitized to p-phenylenediamine.

Br J Dermatol. 2015 Jan;172(1):138-44

Authors: Pot LM, Coenraads PJ, Goebel C, Blömeke B

Abstract
BACKGROUND: A 30-min application of a hair dye product containing 2% p-phenylenediamine (PPD) to subjects diagnostically graded +, showed that 12 of 18 reacted; eight of 18 with a true + and four of 18 with a doubtful (?+) response, whereas six of 18 did not react at all. In vitro skin-binding experiments showed that for diagnostic patch test conditions the measured exposure level (MEL) is more than 10-fold higher than the MEL for hair dyeing conditions.
OBJECTIVE: To further analyse the limited elicitation response of the diagnostically + graded subjects to a PPD hair dye product, under standardized test conditions mimicking product usage, by varying exposure time and dose.
METHODS: A hair dye model formulation containing 2% PPD, applied for 30, 45 and 60 min and a diagnostic PPD TRUE test(®) were applied to assess elicitation responses to increasing PPD exposure levels. Grading was performed according to International Contact Dermatitis Research Group guidelines.
RESULTS: Six subjects were available for this follow-up study. One of six subjects responded with a + elicitation response to the hair dye model applied for 60 min. Four of the five remaining subjects elicited a + response to the PPD TRUE test(®) applied subsequently, while one of five responded doubtfully.
CONCLUSIONS: Increasing the PPD exposure time twofold–resulting in a 5-6% increase of sensitivity of this hair dye model test–or further extending the exposure time 48-fold, was found sufficient to increase the MEL above the thresholds needed to elicit individuals with a + diagnostic PPD patch test who did not react to typical hair dye use conditions with a MEL of about 6·8 μg cm⁻². This analysis confirms that consideration of the MEL is a useful tool to better characterize thresholds of elicitation than consideration of the applied dose alone.

PMID: 24890083 [PubMed – indexed for MEDLINE]

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p-Phenylenediamine exposure in real life?-?a case-control study on sensitization rate, mode and elicitation reactions in the northern Netherlands.

Posted on February 14, 2016 by


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p-Phenylenediamine exposure in real life - a case-control study on sensitization rate, mode and elicitation reactions in the northern Netherlands.

Contact Dermatitis. 2015 Jun;72(6):355-61

Authors: Vogel TA, Coenraads PJ, Bijkersma LM, Vermeulen KM, Schuttelaar ML, EDEN Fragrance Study Group

Abstract
BACKGROUND: The prevalence of p-phenylenediamine (PPD) sensitization is 4% in the patch tested population and varies between zero and 1.5% in the general population. Hair dye is a recognised sensitization source.
OBJECTIVES: To define the prevalence rates of PPD sensitization in the general and patch tested populations of The Netherlands, and to gain insights into relationships between patch test strength and exposure sources.
METHODS: Patch test database cases were matched with population-based controls. Analyses were performed based on demographic details, patch test reactions, and potential PPD exposure.
RESULTS: PPD sensitization occurred in 3.3% of the patch tested population and in 1.3% of the general population. Hairdressers had a 4.4-fold increased chance of being sensitized to PPD (p = 0.041), and black henna tattoos showed a tendency for a 2.3-fold increased chance of sensitization (p = 0.081). Weak elicitation reactions were present in hairdressers and consumers. However, cases who had had black henna tattoos showed significantly more (extremely) strong patch test reactions upon elicitation (p = 0.015).
CONCLUSIONS: The prevalence rates in the patch tested and general population of The Netherlands are comparable with the prevalence rates of other mid-European centres. PPD sensitization is often attributed to hair dye. However, this study shows that subjects sensitized by black henna tattoos present with very severe elicitation reactions, emphasizing the need for more strict policing the prohibition.

PMID: 25824090 [PubMed – indexed for MEDLINE]

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Atypical presentation of painful vesicles on the hands and feet in an immunocompromised adult.

Posted on February 4, 2016 by

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Atypical presentation of painful vesicles on the hands and feet in an immunocompromised adult.
J Clin Virol. 2015 Nov 17;
Authors: Christoffers WA, Riezebos-Brilman A, Kardaun SH
PMID: 2683087… Continue reading →






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