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Contributors
Meta
Monthly Archives: November 2021
Natural Occurrence of Autoantibodies against Basement Membrane Proteins in Epidermolysis Bullosa
No abstract Continue reading
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Natural Occurrence of Autoantibodies against Basement Membrane Proteins in Epidermolysis Bullosa
No abstract Continue reading
Comments Off on Natural Occurrence of Autoantibodies against Basement Membrane Proteins in Epidermolysis Bullosa
Therapeutic Prospects of Exon Skipping for Epidermolysis Bullosa
Epidermolysis bullosa is a group of genetic skin conditions characterized by abnormal skin (and mucosal) fragility caused by pathogenic variants in various genes. The disease severity ranges from early childhood mortality in the most severe types to occasional acral blistering in the mildest types. The subtype and severity of EB is linked to the gene involved and the specific variants in that gene, which also determine its mode of inheritance. Current treatment is mainly focused on symptomatic… Continue reading
Comments Off on Therapeutic Prospects of Exon Skipping for Epidermolysis Bullosa
Therapeutic Prospects of Exon Skipping for Epidermolysis Bullosa
Epidermolysis bullosa is a group of genetic skin conditions characterized by abnormal skin (and mucosal) fragility caused by pathogenic variants in various genes. The disease severity ranges from early childhood mortality in the most severe types to occasional acral blistering in the mildest types. The subtype and severity of EB is linked to the gene involved and the specific variants in that gene, which also determine its mode of inheritance. Current treatment is mainly focused on symptomatic… Continue reading
Comments Off on Therapeutic Prospects of Exon Skipping for Epidermolysis Bullosa
Palbociclib dose reductions and the effect on clinical outcomes in patients with advanced breast cancer
CONCLUSION: Palbociclib dose reductions occurred in real-world practice similarly to the PALOMA-3 trial. Patients with dose reductions had no poorer outcomes compared to patients not requiring a dose reduction. Older patients treated with palbociclib had more frequent dose reductions, but this did not appear to affect OS. Continue reading
Comments Off on Palbociclib dose reductions and the effect on clinical outcomes in patients with advanced breast cancer
Palbociclib dose reductions and the effect on clinical outcomes in patients with advanced breast cancer
CONCLUSION: Palbociclib dose reductions occurred in real-world practice similarly to the PALOMA-3 trial. Patients with dose reductions had no poorer outcomes compared to patients not requiring a dose reduction. Older patients treated with palbociclib had more frequent dose reductions, but this did not appear to affect OS. Continue reading
Comments Off on Palbociclib dose reductions and the effect on clinical outcomes in patients with advanced breast cancer
Hand eczema and lifestyle factors in the Dutch general population: Evidence for smoking, chronic stress, and obesity
CONCLUSIONS: The current study indicates that lifestyle factors are associated with HE. Advice regarding lifestyle factors might contribute to enhance overall health, of which HE might possibly benefit in conjunction. Further studies should also focus on the association between lifestyle factors and the severity and prognosis of HE rather than on occurrence alone. Continue reading
Comments Off on Hand eczema and lifestyle factors in the Dutch general population: Evidence for smoking, chronic stress, and obesity
Hand eczema and lifestyle factors in the Dutch general population: Evidence for smoking, chronic stress, and obesity
CONCLUSIONS: The current study indicates that lifestyle factors are associated with HE. Advice regarding lifestyle factors might contribute to enhance overall health, of which HE might possibly benefit in conjunction. Further studies should also focus on the association between lifestyle factors and the severity and prognosis of HE rather than on occurrence alone. Continue reading
Comments Off on Hand eczema and lifestyle factors in the Dutch general population: Evidence for smoking, chronic stress, and obesity
Clinical response to rituximab and improvement in quality of life in patients with bullous pemphigoid and mucous membrane pemphigoid
No abstract Continue reading
Comments Off on Clinical response to rituximab and improvement in quality of life in patients with bullous pemphigoid and mucous membrane pemphigoid
Clinical response to rituximab and improvement in quality of life in patients with bullous pemphigoid and mucous membrane pemphigoid
No abstract Continue reading
Comments Off on Clinical response to rituximab and improvement in quality of life in patients with bullous pemphigoid and mucous membrane pemphigoid