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Meta
Monthly Archives: February 2022
The Mitochondrial Epigenome: An Unexplored Avenue to Explain Unexplained Myopathies?
Mutations in either mitochondrial DNA (mtDNA) or nuclear genes that encode mitochondrial proteins may lead to dysfunctional mitochondria, giving rise to mitochondrial diseases. Some mitochondrial myopathies, however, present without a known underlying cause. Interestingly, methylation of mtDNA has been associated with various clinical pathologies. The present study set out to assess whether mtDNA methylation could explain impaired mitochondrial function in patients diagnosed with myopathy… Continue reading
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The Mitochondrial Epigenome: An Unexplored Avenue to Explain Unexplained Myopathies?
Mutations in either mitochondrial DNA (mtDNA) or nuclear genes that encode mitochondrial proteins may lead to dysfunctional mitochondria, giving rise to mitochondrial diseases. Some mitochondrial myopathies, however, present without a known underlying cause. Interestingly, methylation of mtDNA has been associated with various clinical pathologies. The present study set out to assess whether mtDNA methylation could explain impaired mitochondrial function in patients diagnosed with myopathy… Continue reading
Comments Off on The Mitochondrial Epigenome: An Unexplored Avenue to Explain Unexplained Myopathies?
Response to: Effect of dose reductions on clinical outcomes, or of outcomes on dose reductions?
No abstract Continue reading
Comments Off on Response to: Effect of dose reductions on clinical outcomes, or of outcomes on dose reductions?
Response to: Effect of dose reductions on clinical outcomes, or of outcomes on dose reductions?
No abstract Continue reading
Comments Off on Response to: Effect of dose reductions on clinical outcomes, or of outcomes on dose reductions?
Exposure and work-related factors in subjects with hand eczema: Data from a cross-sectional questionnaire within the Lifelines Cohort Study
CONCLUSION: Preventive strategies for HE should focus on avoidance of all wet exposure, regardless of origin. In addition, job tasks instead of job title should be taken into account. As previous results on the association between HE and socioeconomic factors differ, future research should focus on a uniform definition of socioeconomic status. Continue reading
Comments Off on Exposure and work-related factors in subjects with hand eczema: Data from a cross-sectional questionnaire within the Lifelines Cohort Study
Exposure and work-related factors in subjects with hand eczema: Data from a cross-sectional questionnaire within the Lifelines Cohort Study
CONCLUSION: Preventive strategies for HE should focus on avoidance of all wet exposure, regardless of origin. In addition, job tasks instead of job title should be taken into account. As previous results on the association between HE and socioeconomic factors differ, future research should focus on a uniform definition of socioeconomic status. Continue reading
Comments Off on Exposure and work-related factors in subjects with hand eczema: Data from a cross-sectional questionnaire within the Lifelines Cohort Study
National survey on the current practice and attitudes toward the management of chronic subdural hematoma
CONCLUSION: Variation was found regarding preferential CSDH-treatment. However, this is considered not to be insurmountable when implementing evidence-based treatments. This baseline inventory on current clinical practice and current attitudes toward CSDH-treatment is a stepping-stone in the eventual development and implementation of a national guideline. Continue reading
Comments Off on National survey on the current practice and attitudes toward the management of chronic subdural hematoma
National survey on the current practice and attitudes toward the management of chronic subdural hematoma
CONCLUSION: Variation was found regarding preferential CSDH-treatment. However, this is considered not to be insurmountable when implementing evidence-based treatments. This baseline inventory on current clinical practice and current attitudes toward CSDH-treatment is a stepping-stone in the eventual development and implementation of a national guideline. Continue reading
Comments Off on National survey on the current practice and attitudes toward the management of chronic subdural hematoma